CRYSTALLOGRAPHY

        • Systematic studies (up to 3600 conditions)
        • Optimization (additives, seeding)
          Crystallization by vapour diffusion, liquid/liquid diffusion and under oil, test of diffractive quality (in situ or at the ESRF/Grenoble)

STRUCTURAL ANALYSES

        • Structural and dynamic analyses
        • Folding analysis
        • Structure of protein/nucleic acid, protein/protein complexes & oligomers
          2D NMR, 3D double resonance, 4D, X-ray diffractometry, cryomicroscopy, electron (cryo)tomographyAnalyse structurale et dynamique

RATIONAL DESIGN OF ACTIVE MOLECULES

        • Identification of potential ligands, analysis and refinement
        • Screening of ligand libraries (<100)
          Modelling, STD-NMR, chemical shift mapping

PREDICTIVE ANALYSES & MODELLING

        • Predictive analysis of primary structures
        • Sequence-structure comparison
        • Prediction of active sites
        • Macromolecular modelling Étude systématique (jusqu’à 3600 conditions)
        • Optimisation (additifs, seeding)   

FACILITY