ANALYSIS OF INTERACTIONS

        • Ligand-target interaction (affinity, selectivity, Kd, stoichiometry)
        • Oligomerization
        • Analysis of  the molecular kinetic mechanisms
        • Determination of concentrations
        • Structure-function studies
        • Selection and optimization of molecules in “drug discovery”     
          Surface Plasmon Resonance (SPR), fluorescence anisotropy, time-resolved fluorescence, techniques of micro-calorimetry, fluorescence correlation spectroscopy (FCS)

PEPTIDE ARRAYS

        • Mapping and characterization of epitopes and interaction sites

STABILITY & AGGREGATION ANALYSIS

        • Study of the thermic and chemical stability of proteins and peptides
        • Study of the denaturation of proteins or peptides
        • Formulation, storage stability
        • Screening of buffers, detergents, ligands
        • Determination of the apparent or absolute molecular weight
          Nano-differential scanning, dynamic light scattering, circular dichroism, SEC-MALS

FACILITIES