CONVENTIONAL PHENOTYPING

        • Various types of sample: serum, plasma, urine, liquide céphalorachidian liquid
        • From 2 μL to 95 μL sample volume
        • Lipids (LDL & HDL cholesterol, triglycerides)
        • Lactate, glucose, fructosamin
        • Liver related metabolites (uric acid, albumin, ALanin & ASpartate aminoTransferase/transaminases, conjugated/free bilirubin, Cholesterol, Iron, Gamma-Glutamyl-Transpeptidases, glucose, alcaline phosphatase, lactate, Lactate DeHydrogenase)
        • Kidney-related metabolites (uric acid, albumin, Calcium, Creatinin, phosphorus, triglycerides, µ-albumin, lactate, CO2, Magnesium, urinary proteins, sodium, potassium, chlorides, urea)
        • Pancreas-related metabolites (bilirubin, calcium, Gamma-Glutamyl-Transpeptidases, glucose, lipase, alacaline phosphatase, total proteins, amylase, magnesium)
        • Muscle-related (ALanine & ASpartate aminoTransferase/transaminases, Creatin Kinase, creatinin, triglycerides, lactate, µ-albumin, Lactate DeHydrogenase)
        • Thyroïd-related metabolites (calcium, cholesterol, Creatin Kinase, Gamma-Glutamyl-Transpeptidases, phosphorus, magnesium)
        • Spectrophotometry (Colorimetry and Turbidimetry) & Potentiometry (Direct -Serum or Plasma and Indirect - Urine).

MASS SPECTROMETRY PHENOTYPING

Using the targeted metabolomics application.

LIVE MONITORING OF CELL RESPIRATION & GLYCOLYSIS

        • Analyses on cultured cells, isolated mitochondria, organoids, small tissue samples, or small organisms (zebrafish) (Seahorse, up to 96 samples/Oroboros, 2 samples)
        • Drug dispensing possible
        • Metabolic phenotyping including measurements of oxygen consumption (OCR) and acidification of the extracellular medium (ECAR), mitochondrial ATP, H2O2 production, glycolysis and fatty acid oxidation.

METABOLISM OF MODEL ANIMALS

        • Metabolic cages with Oxymax meters (open-circuit calorimeter) for oxygen consumption (VO2) and CO2 production rates measurements.
        • Telemetric monitoring of body temperature
        • Body composition measurements of fat, lean, free water, and total water masses in live animals
        • Conscious rats or mice from 10 g upt to 700g.
        • NMR Body composition analysis

FACILITIES